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Here, we show that diet-induced obesity (DIO) causes massive remodeling of circadian enhancer activity in mouse liver, triggering synchronous high-amplitude circadian rhythms of both fatty acid (FA) synthesis and oxidation.
Also massive remodeling of single chromosomes, termed chromothripsis, involving ten to hundreds of genomic rearrangements were detected in CLL cells and found to be associated with poor clinical outcome [31], [32].
George Steinbrenner purchased the Yankees in 1973 and oversaw the massive remodeling of Yankee Stadium in the mid-1970s.
As MDA-MB-231 cells showed massive remodeling of deposited extracellular matrices, such as fibronectin (not shown), which is a characteristic of matured integrin-based adhesion structures50, MCF7 cells and siRNA-treated MDA-MB-231 cells hardly show such properties, suggesting that the adhesion structures in the latter cells remain less mature.
Taken together, these data suggest that at least 2%3%% of all cancers show evidence for massive remodeling of a single chromosome, involving tens to hundreds of genomic rearrangements.
4, 5 The intricateness in the massive remodeling of host RBCs induced by the parasite and the unusual plasticity of the parasite's metabolism through the various stages of its life cycle has been well studied.
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Enlargement of the adipose mass, such as that seen in the post-weaning period and upon HFD feeding, involves massive remodelling caused by increased cell size and number and by new vessel formation.
Incredibly, after a massive remodel and second-story addition to their 1959 Newport Beach bungalow, they both got what they wanted.
During his parks tenure, Disney opened Hong Kong Disneyland and began a massive remodel of the California Adventure theme park in Anaheim.
Moreover, recent data show that genetic inactivation of Pten in stromal fibroblasts of mouse mammary glands accelerates tumour initiation and progression by massive remodelling of extracellular matrix (ECM) and increased angiogenesis (Trimboli et al, 2009).
The data indicates that azole resistant Candida undergoes massive lipidome remodeling where certain common lipid species are more significantly changed between most of the AS and AR isolates (Figure 4 and Figure 5, Supplementary Table S2).
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