Sentence examples for massive overexpression of from inspiring English sources

Although scientists have successfully induced amyloid-β transmission in rodents, these experiments relied on "massive" overexpression of the protein, says Samuel Gandy, a neuropathologist at the Icahn School of Medicine at Mount Sinai in New York City.

Therefore, we propose that retroviral integration at Evi32 leads to a massive overexpression of Prdm14 contributing to lymphoma in these mice.

As massive overexpression of APP can lead to changes in the APP trafficking pathway, we decided to use the more moderate, neuron-specific synapsin promoter to drive pHAPP expression.

We suspect that it most likely does, but not before such a massive overexpression of CF2 (as the 88F enhancer is very strong, [21]) does its damage and disrupts IFM development.

These results show directly that palmitoylation of the Swf1 substrate Tlg1 cannot be carried out by other PATs, and confirm that, in vivo, this activity is exclusively performed by Swf1, because only upon massive overexpression of Pfa3 a small degree of complementation is observed.

The invariant predicts that massive overexpression of Ypd1 should not cause phosphorylation of Hog1.

Nowadays, the focus in metabolic engineering research is shifting from massive overexpression and inactivation of genes towards the model-based fine tuning of gene expression.

The Xenopus experiments suffer from massive overexpression and pure gain-of-function approaches.

In heterologous systems and tumor cells, although not in the brain, it could be argued that the expression of the channel in the nuclear envelope is an artifact of massive overexpression.

In analogy to previous findings in myoepithelial cells of human breast tissue (Grunewald et al, 2006), a massive overexpression in vascular smooth muscle cells could be observed.

GRK2 lacked efficacy at both endothelin and alpha(1 -adrenergic receptors despite massive overexpression.