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1.36am BST Fifth set: Murray* 7-6, 7-5, 2-6, 3-0, 3-0 Djokovic Mark Jelbert has an undoubted point: The idea that Murray can only lose this by throwing it away is a massive insult to Djokovic who's been magnificent - I definitely want Murray to win but either would make a worthy champion.
When cells are coping with a massive insult that is potentially harmful for the entire organism, mitochondria release into the cytoplasm molecules able to trigger cell death, such as cytochrome- c or apoptosis-inducing factor.
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This positive feedback mechanism might function counter to homeostatic mechanisms in the presence of a massive inflammatory insult and hasten death of a severely ill animal.
Thus, even though random breakage or fragile sites could explain genetic alterations after a massive genotoxic insult , they probably have a minor role in the genesis of CIN under normal circumstances.
While for very large S there may not be a well-defined maximum death rate as massive cellular insult will result in necrosis, it is unlikely that necrosis will occur under the physiologically feasible range for S. Therefore, we assume apoptosis occurs at a defined maximum rate for large S and again choose a Hill function to represent the apoptotic response to ROS: S q /(ω q + S q ).
This suggests that the native inflammatory system, geared toward mitigating less severe injuries, is ill-equipped to regulate the massive physiologic insults produced by blast injuries (Hawksworth et al., 2009).
In massive cellular insults like ischemia, involving metabolic failure, loss of Ca2+ homeostasis, and excitotoxicity, scavenger activity or one-target antioxidant mechanisms (NMDA receptor blockers, chain-breaking vitamin E, or pure scavenger molecules such as boldine) may fail to protect cells from free radical damage.
It then evolves in response to a series of sequential and poorly understood insults including massive fluid resuscitation, mechanical ventilation, vasoactive therapy and nosocomial infection, and the ecological derangements induced by broad-spectrum antibiotic therapy.
Related: You'll Get a Massive Prison Sentence If You 'Insult ' Thailand's Monarchy on Facebook.
Which frankly, considering the serious implications of the massive hypocrisy involved, is an insult to sex workers.
In New York, Governor David Paterson has taken a Draconian stance in regard to the SUNY system, proposing massive aid reductions and, adding insult to injury, also taking 90percentnt of the funding from a compensatory tuition increase.
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Real-world application tested
The phrase "massive insult" functions as a noun phrase where the adjective "massive" modifies the noun "insult", intensifying its meaning. As Ludwig AI confirms, it's a usable expression to describe something extremely offensive. The phrase acts as a subject complement or object, as seen in Ludwig's examples.
Expression frequency: Rare
