Moreover, anecdotal cases of giant cell hepatitis, granulomatous hepatitis, massive hepatic necrosis, cholangitis, isolated portal hypertension, Budd-Chiari syndrome, and liver infarction have also been described.
It is now accepted that the atypical ductular reaction observed in livers with sub-massive hepatitis represents the proliferation of hepatic progenitor cells, similar to rat oval cells and are able to differentiate towards the biliary and the hepatocytic lineage [23] [24].
In Egypt during the 1970s and 1980s, a poorly controlled nationwide campaign to treat the parasitic disease bilharzia by multiple drug injections led to the massive spread of hepatitis C. Some 6m Egyptians are currently infected, largely as a result of the campaign.
As an example, agonistic anti-CD95 antibodies caused massive CD95-induced hepatitis in normal mice but increased liver regeneration in mice subjected to hepatectomy [ 3].
Long says one of the new drugs, Rifampin, gave his father hepatitis, caused massive weight loss and left him with brain damage that rendered him unable to walk unassisted.
Pathological examination of her liver uncovered massive necrosis without significant hepatitis, which is not specific for a particular etiology.
Elevated AFP is reported in yolk sac tumors, cirrhosis, massive liver necrosis, chronic hepatitis, pregnancy, fetal distress, and fetal neural tube defects [ 8].
Bilateral metastases in inguinal lymph nodes, massive pulmonary tumour embolization, hepatic fatty change, mild multifocal neutrophilic hepatitis, cystic ovaries, and moderate cystic endometrial hyperplasia were also detected.
The former usually presents as severe acute hepatitis with a massive rise in transaminases, occasionally leading to acute liver failure.
The results have been equally massive: 3.4 million lives saved from hepatitis B, which causes liver cancer, 1.2 million lives from measles, 560,000 from the Hib bacteria, 474,000 from whooping cough, 140,000 from yellow fever and 30,000 from polio.
Other changes in the liver included a moderate multifocal suppurative hepatitis (two males, nine females; 10.0%), massive multifocal to coalescing granulomatous hepatitis with intralesional parasites (parts of Cysticercus pisiformis) (three males, one female; 3.6%; Fig. 4b), and in two cases (one male, one female; 1.8%) biliary duct adenomas.
