We found no fibrinogen concentrate comparator studies in patients with haemorrhage due to massive trauma, although efficacy across all assessed outcomes was reported in a number of noncomparator trauma studies.
This would have been a massive endeavour, the efficacy of which would have depended largely on the speed at which it could have been implemented, which would in turn have been limited by the rate of production of effective vaccine doses.
However, they are hard pressed to counter our historical experience from the 1930s and early 1940s of the efficacy of massive federal spending in times of economic crisis.
In case of a fast and massive pandemic (profile A), efficacy and coverage play a moderate role for several interventions, whereas in a progressive and long lasting pandemic (profile B), such correlations do not clearly appear, except for speed of intervention (as mentioned above) and pre-pandemic vaccination.
Reduction of drug efficacy in massive tumours was described by a simple link between the fraction of surviving cells at each treatment and the growth rate.
Lastly, we reviewed the FBNc efficacy at treating massive haemorrhage in non-trauma patients with heterogeneous diagnoses.
Indeed, clinical trials with IL-6 antibodies have shown good antitumor efficacy leading, yet, massive systemic elevations in IL-6.
The aim of this study is to develop an advanced 3D aligned collagen/silk scaffold (ACS) and investigate its efficacy in a rabbit massive rotator cuff tear model.
These results suggest that rFVIIa has high efficacy in treatment of massive hemorrhage and reducing the need for hemotransfusions when other hemostatic therapy has failed.
However, because the AngioJet Xpeedior is not designed to treat vessels greater than 12 mm in diameter, its therapeutic efficacy in the treatment of massive PE remains limited [ 21– 23].
