The same media that despised trash-talk as a signature of massive cultural dysfunction now embraces it.
Never mention state inefficiencies, infrastructural mayhem, proliferating parastatal behemoths, repetitive government disasters, massive institutional dysfunction, energy outages, failed or failing states which are only exceptions proving your prescient economic rule.
But most of my "project the future" scenarios involved massive government dysfunction and doom.
Neurotropic viruses can cause massive neuronal dysfunction and destruction that lead to neurological diseases.
Down-regulation of pathways enriched for Oxidative Phosphorylation, citrate cycle, and fatty acid metabolism suggested an energy crisis with massive mitochondrial dysfunction, supporting the observed necrosis in the cardiac histopathology.
Multiple trauma is life-threatening, not only from the initial trauma insult alone, but also from the subsequent massive immunological dysfunctions and metabolic alterations. 1 Multiple trauma is characterised by impairment in the immune response 2 3 that is associated with an increased rate of infectious complications and death.
Heart failure, caused by massive loss or dysfunction of hCMs, is the main cause of death and morbidity in the developed world.
Even though surgical excision is the most effective treatment, an excessive excision brings about motor dysfunction, massive bleeding, cosmetic problems, and nerve damage in patients with widespread lesions because of the complicated anatomy of the head and neck region [3, 17].
These ROS, in turn, activate the permeability transition pore, triggering organelle dysfunction, massive release of mitochondrial apoptotic factors, and ROS and eventually inducing cell apoptosis [ 71].
