In Hr knockout mice, a massive disintegration and apoptosis was observed in the bulb of the hair follicle during the first hair cycle in the mouse [12].
In striking contrast, CSMN of UCHL1−/− mice displayed massive disintegration with profound vacuolization and breakdown of cell membrane especially along the apical dendrites (Fig. 4 E, J– O; UCHL1−/−, 42 ± 4%, n = 167 apical dendrites, n = 3; P < 0.01; and WT, 7%, n = 281 apical dendrites, n = 3).
Rapid establishment of Foc1 coupled with massive tissue disintegration led to the total collapse of root architecture ultimate causing wilting of susceptible plants at about 12dpi, whereas resistant plants showed minimal signs of stress even at later stages of infection [ 15– 17].
The upside of the bargain was that it ensured South Africa transitioned from apartheid to democracy without massive bloodshed or economic disintegration.
"The reason I wanted it out now is, it addresses big issues that are not being addressed in this campaign: the massive and growing deficit, the disintegration of the culture and a Wilsonian foreign policy that means war ad infinitum," he said.
Known also as the Crab Nebula and dimly visible as a small oval smudge near the ninth magnitude, it is the expanding dusty debris from the disintegration of a massive star in a supernova explosion observed by Chinese astronomers in 1054.
With a report about the break-up of the Arctic's Ward Hunt Ice Shelf earlier this week and reports a few weeks ago about the further disintegration of the massive Wilkins Ice Shelf in Antarctica, I'll say it again... something isn't right at the Poles.
One way to explain that energy bump would be by the disintegration or annihilation of a very massive dark particle.
Histology of the liver was almost same in all five specimens which showed distortion of liver architecture, red cell extravasation with collapse in the reticulin frame work and disintegration of hepatocyte nuclei suggestive of massive liver cell necrosis.
Furthermore, the Chinese communist leaders, remembering the disintegration of the Soviet Union in 1991, the massive June 4th , 1989Tienanmen demonstrations and Japanese atrocities and humiliation in the Anti-Japanese War (1937 to 1935), are leery of failed adventures.
Adar1 mutant mice die by embryonic day E12.5 with massive overproduction of IFN, loss of embryonic liver hematopoietic cells, liver disintegration, and widespread apoptosis (Hartner et al., 2004; Wang et al., 2004).
