Sentence examples for massive differentiation from inspiring English sources

The massive differentiation of these groupings of progenitors into differentiated cells, and thus into tissues, involves the substantial up-regulation of synthesis of complex and tissue-specific extracellular matrices.

Complete sustained regression, concomitant with massive differentiation and/or apoptosis, and partial regression are both observed.

The observed Notch activity in the V1 domain of Jag1 mutant embryos favours the hypothesis that Dll1-expressing cells located at the boundary between the V0/V1 and V1/V2 domains are capable of signalling to neural progenitors in the adjacent V1 domain, preventing massive differentiation of V1 INs.

The secondary transition, from E13.5 to E15.5, involves massive differentiation of beta cells and continued expansion and branching [ 11].

Inactivation of individual Klf genes is thus detrimental to self-renewal but is not sufficient to trigger the massive differentiation observed following triple inactivation.

In general, massive differentiation of epithelial breast cells in response to the increased release of ovarian hormones during pregnancy has been proposed as an explanation for both the elevated short-term breast cancer risk after pregnancy, and the extended protective effect of pregnancy (Lambe et al., 1994; Albrektsen et al., 2010).

The study suggested that HPC represent a source of adipogenic tissue within the skeletal muscle in pathological conditions as they spontaneously differentiated to adipocytes, but they can be conditioned towards a massive myogenic differentiation if cocultured with LPC.

The high proliferative spontaneously differentiated to adipocytes but they could still be conditioned towards a massive myogenic differentiation if co-cultured with LPC.

Indeed, we show that Notch signalling is active in ES cell derived neuroepithelial rosettes and that chemical inhibition of Notch activity results in massive neuronal differentiation of rosette NPs, similarly to what has been described during CNS embryonic development (reviewed in [11], [21]).

Previously used procedures failed to yield long-term proliferating but immature erythroid progenitors, due to massive spontaneous differentiation [ 12, 29].

This microcircuit architecture shows a connectivity peak at PN10, coinciding with a switch to massive oligodendrocyte differentiation.