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An important recognition is that the covariance of residues in a series of homologous functional proteins provides a massive constraint on the inter-residue contacts and thus what structures they might adopt, and substantial advances have recently been made by a number of groups in this regard.
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The economy has weakened due to the massive constraints placed upon it by the conspicuously absent chancellor, and the stability they promised, now so desperately needed, has not been delivered.
The response to Typhoon Haiyan in the Philippines showed the challenges of providing aid amidst massive logistical constraints.
What's more, the massive complex dependency and constraint relationships between features present another huge challenge for optimization.
This data set thus serves as an ideal proving ground for the approach of identifying functional constraint using massive amounts of polymorphism data, which will soon be available for nuclear genomes.
The last constraint is used to filter a massive set of unpromising subgraphs from the search space.
The accruing combination of enormous wealth, acclaim as a revolutionary genius, freedom from studio constraints and massive use of cocaine meant that he pretty much went gaga.
All the same, this assertion: Last week, when Angela Merkel's government was preparing position papers on how to insert prospects of growth into Germany's bleak covenant for resolving the European Union's debt crisis via massive economic and financial constraints, it signaled the dilution of Europe's strongest swig of unchallenged German leadership since World War II.
Our intuition suggests that the answer is "no" because of the massive data, extreme time constraints requiring near real-time responses, and the largely data-driven nature of the problem.
"However, in the past couple of years, a number of trends including government adoption of the cloud, budget constraints, a massive government personnel retirement cycle and an open data movement have coalesced to create an openness on the part of government agencies to embrace new technologies and a dramatically shortened sales cycle — our portfolio companies' average is just 86 days".
The government's attitude towards collaboration is changing, slowly: I think there is going to be massive change given the financial constraints and current commitment of government to externalisation and the development of co-operatives and other forms of social enterprise.
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