Sentence examples for massive cell proliferation from inspiring English sources

It is known that in tumor tissue, massive cell proliferation and cell death often coexist at the same time.

While many cancers are characterized by high cellular turnover including massive cell proliferation and cell death, the concentration of the cell death end products nucleosomes in serum varies between different types of cancers and also between individuals [ 43, 44].

During normal T-cell differentiation, preTCR-induced signaling leads DN thymocytes to cross the so-called β-selection checkpoint, which results in massive cell proliferation and the induction of a developmental process marked by the expression of both CD4 and CD8 co-receptors, thus generating DP thymocytes [ 31].

From this massive B cell proliferation, some of the cells form strong antibodies and then undergo further differentiation into either plasma cells or memory B cells, whereas others with disadvantageous antibody gene mutations undergo cell death.

The phenotype of CTLA4 knock out mice, which develop massive T cell proliferation and autoimmune infiltration of multiple organs within weeks after birth, provides evidence of the critical role of CTLA4 in regulation of immune responses [6], [7].

These include increased intestinal permeability, changes in mucosal crypt depth, massive epithelial cell proliferation, lymphocyte infiltration, and proinflammatory activity, before the development of both insulitis and diabetes [ 68, 69].

Chronic liver injury caused by HBV, HCV, chronic alcohol consumption, nonalcoholic steatohepatitis (NASH), hereditary hemochromatosis, primary biliary cirrhosis (PBC), and alpha-1 antitrypsin deficiency leads to permanent hepatocyte damage followed by a massive compensatory cell proliferation and regeneration in response to cytokine stimulation (Table 1).

The severity of these obesity-related pathological alterations, such as glomerular and tubular degeneration, glomerulosclerosis, interstitial fibrosis, and massive regenerative cell proliferation, was increased in DIOres rats compared with controls, and was most pronounced in DIOsens rats (Fig. 2A-C, Table 2).

Superantigens (SAGs) elicit massive T-cell proliferation through simultaneous interaction with MHC and TCR molecules.

These results suggested that quantitatively, the rRNA synthesis controlled by basonuclin was minor compared with the massive synthesis required for cell proliferation.

In contrast, TL therapy induced massive necrosis, significantly inhibited cell proliferation, particularly at the tumour centre, and induced a 20-fold elevation in the number of apoptotic cells.