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For example, in Alzheimer disease, the hippocampus undergoes massive cell loss, which is associated with memory deficits that manifest in early stages of the disease.
Myocardial infarction typically results in fibrous (collagen) scar formation and permanently impaired cardiac function because, after a massive cell loss due to ischaemia, the myocardial tissue lacks significant intrinsic regenerative capability.
With this platform, they could both keep the cells within the infarct bed (in contrast to the massive cell loss associated with infusion of cells alone) and enhance cell survival and function in the infarct bed, where most of the cells would have died because of the obstruction of their blood supply.
Stem cell-based therapies, including the use of engineered cardiac tissues, have the potential to treat the massive cell loss and pathological remodeling resulting from heart attack.
However, in this current report, we analyzed unaffected brains, which allow us to overcome methodological and interpretative challenges that arise from the massive cell loss, particularly neuronal loss, along with other pathologic processes accompanying neurodegeneration that may influence expression.
This massive cell loss is first observed as a multilayering of enterocytes that contributes to the characteristic increase in gut width observed upon infection.
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86, 87 Testes and ovaries from ATM−/− animals display massive germ cell loss.
Hence, germ cells might be sensitive to starvation condition, and the abrupt energy homeostasis shifting during neonatal transition causes massive germ cell loss.
We have previously demonstrated that MILON mice develop a massive nerve cell loss in different regions of neocortex and medial hippocampus at the end of their life (24).
The massive germ cell loss shortly after parturition is a mysterious phenomenon in the reproductive biology, and our research might provide a plausible explanation to this phenomenon.
As at least partial recovery of brain shrinkage occurs after reversal of high GC exposure [ 19, 201] making massive, irreversible, cell loss unlikely [ 53, 75, 85, 242].
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