Although LDH is related to tumor burden, LDH is also high in liver diseases, in hemolysis and in other situations with massive cells destruction.
Massive cell death causes destruction in the tissue, resulting in widespread cell relocation and rupture of blood vessels.
The initial damage seems not to be massive cell death and tight junction destruction, but rather expulsion of senescent single cells as observed as prerequisite for Listeria invasion [36].
To determine the reasons underlying the massive cell death in mutant conceptuses and eventual embryo destruction, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) staining was used to detect the ratio of apoptotic cells in wild-type and Rab10 −/− embryos (Fig. 2B).
On the other hand, EV infection might be responsible for a fulminant form of T1D reported in Japan, which is characterized by massive beta cell destruction in the absence of autoantibodies against beta cell antigens [ 34, 35].
As the catalytic activity of sPLA2 plays an important role in several of its biological and pharmacological properties, antibacterial activity was used to confirm the decrease in its enzymatic activity by 5CQA, which induced massive bacterial cell destruction.
The "window of opportunity" between the infection and peaking of viremia, prior to massive CD4+ T cell destruction and the establishment of viral reservoirs, seems to be a narrow but crucial period in which an antiretroviral therapy can control viral replication, prevent an extensive CD4+ T cell depletion from occurring and curb generalized immune activation.
Massive cell infiltration, cartilage erosion, and bone destruction were observed in joints of vehicle-treated or celecoxib-treated mice but not in those of TFM-C-treated mice.
Arthritis was not apparent in joints treated with TFM-C compared to the severe arthritis with massive cell infiltration, cartilage erosion and bone destruction seen in joints of animals treated with vehicle.
In chronic hepatitis C virus infection in humans an excess number or function of Tregs can inhibit effector immune responses and thus allow pathogen long-term persistence, up to host cell destruction, leading sometimes to massive liver damage [32].
