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Cracks are created by massive breakage of molecular or atomic bonds.
It is rather a massive breakage of atomic bonds diffused in a volume of characteristic size.
In the case of the bulk material with a sophisticated heterogeneous organization, the crack appears as a result of the development of multiple micro-cracks triggered by the massive breakage of molecular or atomic bonds Fig.
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The massive bond breakage is accompanied by the localized loss of material.
Aimed at controlling the large slippage deformation of the two sides, serious deformation and failure in the corners of the two sides and massive bolt breakage, a "controlling and yielding coupling support" control technology is proposed.
The positive effect of MUS81 on RF restart seen in mouse cells could not be discerned in U2OS cells treated with siRNA against MUS81 after prolonged HU treatment (Petermann et al. 2010), and extensive treatment periods (36 h) have been shown to lead to massive MUS81-induced DNA breakage and cell death (Fugger et al. 2013).
Such bridges may consist of mitotically unstable chromosomes undergoing repeated breakage-fusion-bridge (BFB) cycles, thus causing massive reorganisation of chromosome structure (McClintock, 1940).
Finally, 1 APC was replaced because of breakage observed in a 34-year-old male following massive polyethylene cup wear.
Additionally, during April 2009 three colonies of Acropora millepora with distinct blue pigmentation as a result of physical breakage were identified (fig. 1a) together with three Porites massive species with intense pink pigmentation (fig. 1b) in Pioneer Bay, Orpheus Island on the Great Barrier Reef (GBR).
Thus, even though random breakage or fragile sites could explain genetic alterations after a massive genotoxic insult, they probably have a minor role in the genesis of CIN under normal circumstances.
The analysis of the breakage distribution parameters suggests splitting as the dominant mechanism as opposed to attrition or massive fracture.
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