Sentence examples for massive apoptosis of from inspiring English sources
Suda, J. et al. Knockdown of RIPK1 markedly exacerbates murine immune-mediated liver injury through massive apoptosis of hepatocytes, independent of necroptosis and inhibition of NF-kappaB.
Massive apoptosis of lymphocytes is one of the main drivers leading to immunoparalysis [63].
Indeed, knock down of miR-17-5p isufficientntoto promote massive apoptosis of MYCN-amplified LAN-5 cells.
Previous work demonstrated a defective assembly of synaptonemal complexes and massive apoptosis of spermatocytes in Ubr2−/− mice [26].
Loss of the signal from the spleen 48 hours p.i. could be due to complete destruction of spleen together with the massive apoptosis of lymphocytes [32].
Disruption of PiT1 leads to mid-gestation lethality due to severe defects in liver development, arising from reduced proliferation and massive apoptosis of liver cells.
Recent studies have shown that 5-ALA PDT-induced photodamage causes mitochondrial and nuclear DNA damage; subsequently, massive apoptosis occurs because of mitochondrial release of cytochrome c and activation of caspase in glioma cells (Inoue et al, 2007; Karmakar et al, 2007).
There are two consequences of this: (1) an induction of hid overexpression, which induces massive apoptosis; (2) induction of Flipase recombinase, which in turn drives recombination of the act>stop> lacZ cassette, thus labeling all the cells of the Gal4 domain with indelible activity of the LacZ marker, which encodes the ßgal protein.
Cell treatment combining RMT 5265 with poly(I C) induces massive apoptosis in 3 of 5 malignant cell lines, with obvious synergy of the 2 compounds in two cases.
E50K mice also showed massive apoptosis and degeneration of entire retina, leading to approximately a 28% reduction of the retina thickness.
We previously reported that PRIMA-1 (for 'p53 reactivation and induction of massive apoptosis') restored the transcriptional activity of p53 target genes in breast cancer cells with a p53 mutation.
