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Therefore, the massive annotation of the human transcripts enabled us to determine the transcription characteristics around the TSSs of the protein-coding genes in the chimpanzee, as shown in Additional file 2: Figure S4I, M. The valid reads in our directional RNA-seq data of the mouse cerebral cortex samples covered 25.0% of the mouse genome (Table 1).
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Many applications has been proposed in the literature for the task of image annotation, both for personal use and for massive annotations.
A major drawback of these interactive systems is that they still cannot be considered to be practical tools for a massive database annotation: for instance, consider a case in which a reduction of the 50% of the amount of interactions is achieved; if 1000 onsets had to be annotated, the user would have to deal with 500 elements, which still constitutes a significant workload.
Much of this genomic sequence is relatively poorly annotated and one of the major challenges in bioinformatics is the computational annotation of this massive amount of data in a high-throughput manner [ 2].
The massive increase in sequence and annotation data that can be collected over a short term on any given organism has had major consequences in developmental and evolutionary studies.
This approach could not be realized without the advancement of next-generation sequencing and genotyping technologies, as well as the massive efforts spent in the annotation of the structural and functional properties of the human genome (HapMap and ENCODE projects) [10], [11].
The results of the functional re-annotation indicates a massive presence of genes related to mobile genetic elements, being also the functional class most affected by gene inactivation (447 out of 831 CDSs).
The benefits of the SVM for protein-binding region annotation is demonstrated by the massive reduction in the number of false positive assignments that would be made by tagging all predicted disordered residues as protein binding (method 'DISOPRED3 no DPB SVM').
This work suggests that, during germination, there may be a massive transposon mobilization that may be useful in the annotation of new genome sequences and identification of regulatory mechanisms.
The editors of this Collected Poems have done a splendid job in bringing together that massive body of work under one cover, their meticulous annotations adding a very useful dimension.
In consequence, a massive number of genes could have been missed during genome annotation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com