Sentence examples for massive alterations to from inspiring English sources

So with such massive alterations to the show, can it survive – or will it crumble to be replaced by Cowell's new talent-search project, The X Factor?

By this time, the ships could not use the larger barbette, as it would require massive alterations to the design and would result in substantial weight penalties.

Cancer cells undergo massive alterations to their DNA methylation patterns that result in aberrant gene expression and malignant phenotypes.

Duplicate pairs wherein one copy or both copies have unique exonic sequence to the exclusion of the other copy (partial and chimeric duplicates, respectively) may be expected to display higher rates of pseudogenization, given the massive alterations to the ancestral exon-intron structure entailed during such incomplete duplication events.

He's the chief executive of McDonald's, and he rebuffed rumors that his eatery giant plans massive alteration to its corporate structure.

Such massive alterations have the potential to annihilate secondary pre-mRNA structure and impede cellular mRNA processing leading to exon skipping.

Wow, these are massive alterations, and really speak to how much fan pushback worked here.

Meloni et al. [ 29] recently demonstrated that simulated weightlessness leads to massive alterations in the cytoskeleton of monocytes, which in turn influences motility and recently revealed during an ISS experiment a severe reduction in the locomotion ability of monocytic cells in microgravity [ 30].

The robot walks awkwardly and weighs 330 pounds, so unless you just want to build a malfunctioning Sheriff Pickett and call it a day, you're going to need to make some massive alterations.

Make a massive change to your appearance.

Linear relationships mean that small changes in the environment will not produce massive alterations in activity.