Exact(2)
As millions of people unwittingly do this, we, the non Plaxo users, are hit with a massive aggregate cost: dealing with all of this spam.
Darren Walker, President of the Ford Foundation, in a recent op-ed in the New York Times suggested that the massive aggregate private wealth held and managed by several foundations in our country should be subject to qualitatively new criteria in determining a prospective donee's eligibility for a foundation grant.
Similar(58)
Combined with exponentially growing computing power and the massive aggregates of big data, deep-learning neural networks influence the distribution of work between people and machines.
The mechanism of neutralization involved formation of massive aggregates, with no evidence of virion lysis.
Massive aggregates lasted, almost continuously, for more than five months.
Electron microscopic analyses showed massive and round-shaped electron-dense aggregates in the AVP neurons in FNDI mice with water access ad libitum, as reported previously, while the lumen of the ER adjacent to the massive aggregates was preserved intact.
Electron microscopic analyses in this study clearly demonstrated that, while there were massive aggregates in a sub-compartment of ER lumen of AVP neurons in the FNDI mice with water access ad libitum, there was intact ER lumen adjacent to the aggregates.
Despite the presence of massive aggregates formed in a sub-compartment of the ER lumen of AVP neurons in FNDI mice, there was no significant difference in the expression levels of immunoglobulin heavy chain binding protein (BiP) mRNA between FNDI and WT mice with water access ad libitum (Supplementary Figure S1a).
Consistent with these previous studies, our data demonstrated that, in spite of the presence of massive aggregates in the ER of AVP neurons in FNDI mice, the expression levels of BiP mRNA were similar between FNDI and WT mice with water access ad libitum, suggesting that ERAC formation alleviates ER stress possibly caused by the accumulation of mutant proteins in AVP neurons in FNDI mice.
While in P1-KO muscle fibers desmin-positive aggregates were restricted to perinuclear areas, in MCK-Cre/cKO cells, massive aggregation was observed all over the sarcoplasm (Fig. 2A).
This massive aggregation can contribute to reduce LPS toxicity, through the inhibition of the interaction of LPS with its receptor [30], [31] and by facilitating the phagocytosis of the aggregates by macrophages [32].
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Justyna Jupowicz-Kozak
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