Sentence examples for massive activation of from inspiring English sources

11 In addition, the uncompetitive nature of the memantine's mechanism of action makes its antagonistic activity more potent in areas with massive activation of NMDA receptors.

Sepsis is frequently complicated by acute kidney injury, which is associated with higher risk of in-hospital mortality [3, 4], and by disseminated intravascular coagulation (DIC) due to a massive activation of the coagulation system [5, 6].

A common feature of apoptotic cell death is a massive activation of specialized proteases, caspases, that cleave numerous structural and signaling proteins (Lüthi and Martin, 2007), yielding characteristic morphological and biochemical changes.

Probably because of their repertoire enriched in autospecific cells and the resulting massive activation of peripheral Treg (Fisson et al., 2003; Hsieh et al., 2004; Romagnoli et al., 2002), a very high proportion of thymic Treg are cells that had re-entered the thymus from the periphery (Cowan et al., 2016; Thiault et al., 2015).

Participants with acute motion sickness did not only show low endocannabinoid signaling, they also demonstrated a massive activation of the hypothalamic-pituitary-adrenal (HPA) axis.

For instance, cryptogein induces a rapid and massive activation of anion channel mediated nitrate efflux regulated by Ca2+-dependent events [32], [33].

There was a low level of inherent microglia activation associated with dysmyelination, followed by a massive activation in areas of overt demyelination.

Transfected short DNA molecules with stable blunt ends (false DSB, Dbait, DNA Therapeutics, Paris, France) lure cells that activate the DNA repair process (massive ectopic activation of DNA-PK) by inhibiting breaks repair.

Enhancement of TLR signaling, a previously proposed mechanism, is insufficient to explain massive synergistic activation of cytokine production in human macrophages.

Whole-body cooling appears to be the most effective way to induce massive tonic activation of cutaneous vasoconstrictor neurons [ 22].

The fact that we saw a significant increase in adiponectin concentrations along with clinical recovery, suggests that a massive systemic activation of the immune system as part of the septic response may have a greater impact on serum adiponectin than the obesity status of the patients.