In addition to the massive apoptosis, a morphological abnormality with small and acellular head was observed in hif2α morphants at the 48-h.p.f.
Higher temperatures accelerated spermatogenesis (Figure S1), whereas at 35°C, spermatogenesis did not progress beyond metaphase I and showed abnormalities, such as massive apoptosis in particular amongst spermatocytes, absence of sperm, and a significant decrease in the GSI (Figure 4A,E; Figure S1).
Mitochondrial dysfunction, often characterized by massive fission and other morphological abnormalities, is a well-known risk factor for Alzheimer's disease (AD).
The main abnormality was a massive right-to-left extra-cardiac shunt, without patent foramen ovale, confirming the diagnosis of HPS.
Massive fluid resuscitation followed by hypoperfusion abnormalities in the ICU is a risk factor for development of intra-abdominal hypertension (IAH).
In patients with cancer-related massive hemoptysis, chest radiography may demonstrate abnormalities such as tumors, cavitary lesions, pulmonary infiltrates, and mediastinal masses.
When the HuC promoter is used to drive aSyn expression in larval zebrafish neurons, embryos exhibit massive cell death and gross morphological abnormalities, and die within 2-3 dPrabhudesaietal et al., 2012).
Although most of the early deaths in our study were related to MOF and massive haemorrhage, biological variables exploring hemostasis abnormalities also do not seem very interesting for that purpose.
Many abnormalities predicted the need for massive transfusion and death, but predictive performance was not consistently superior to routine tests.
Many TEG® and ROTEM® abnormalities predict the need for massive transfusion and predict death, but predictive performance is not consistently superior to routine screening coagulation tests.
