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With a mass vaccination level of 5% per day, an average of 18.8 deaths occurred without ring vaccination, and 15.8 deaths occurred when only 5 ring vaccinations per day were possible.
Moreover, when we increased the mass vaccination level to 3%, an average of 28.9 deaths occurred when no ring vaccination was used, but this fell to 22.3 deaths when only 5 ring vaccinations per day were available (again assuming a population of 10000, and 10 index cases).
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Note that many jurisdictions in the United States are planning mass vaccination campaigns which could reach 10%-20 10%-20e population per day, far greater than the mass vaccination levels examined here; it is interesting to note that mass vaccination campaigns may be effective in preventing a widespread epidemic even at much lower levels than are being planned for.
Recent simulation models [ 2- 5] typically conclude that, provided a given smallpox outbreak can be well controlled, the emphasis should be on case isolation, contact tracing and targeted vaccination rather than immediate country-level mass vaccination, due to the frequency of adverse effects from vaccine and the likely high efficacy of other measures.
A mathematical model of cholera transmission was calibrated using these results to extrapolate the effectiveness of mass vaccination at different coverage levels.
The current study focuses on using mass vaccination to achieve a population-level reduction in transmission, with consequent reduction in attack rates, serious illness and death.
Our conclusion that immunity has persisted in the population applies to the underlying population from which the sample was drawn, namely, those eligible and targeted for vaccination during the mass vaccination campaign regardless of individual-level vaccination status.
Monitoring these changes on population level may prove crucial in assessing the effect of mass vaccination and overall HPV vaccine efficacy.
Planning for mass vaccinations Vaccinating children on such a large scale is no easy task.
The overall protection (the combination of direct and indirect effects) from mass vaccination is highest at intermediate coverage levels, and plateaus once a critical vaccination fraction is reached.
The timely and professional handling of the Burkina Faso crisis at local and national levels enabled the continuation of the mass vaccination campaign with no impact on vaccine introduction in other countries.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com