To our knowledge, this is the first study indicating that it may be possible to follow treatment responses to radiotherapy with a high throughput mass spectroscopic method applying multivariate statistical methods.
Mass spectroscopic analysis (see Methods S1) of STAM2 revealed that Y291, Y371 and Y374 are phosphorylated by Fyn (Fig. S3).
Here, gel electrophoretic, mass spectroscopic, and chemical kinetics methods were used to provide evidence that medicinally relevant concentrations of 4 rapidly form covalent adducts with abasic sites in double- and single-stranded DNA under physiological conditions.
In the work described here, we employed gel electrophoretic, mass spectroscopic, and chemical kinetics methods to provide evidence that medicinally relevant concentrations of 4 rapidly form covalent adducts with abasic sites in double- and single-stranded DNA under physiological conditions.
Nine fractions were separated (A-I) then scratched, eluted with the same mobile phase, filtered and the separated fractions were determined and identified using spectroscopic methods (Mass spectrum (MS), Infra red (IR) and Proton H-Nuclear magnetic resonance (H-NMR).
The structure of this isolated compound was determined by a combination of spectroscopic analyses, including IR, H and C NMR, hydrogen-hydrogen correlation spectroscopy (H-H COSY), heteronuclear multiple quantum coherence (HMQC), heteronuclear multiple bond coherence (HMBC), mass spectroscopic data, and chemical methods.
Spectroscopic methods such as mass spectroscopy (MS), infrared spectroscopy (IR) or nuclear magnetic resonance (NMR) spectroscopy are commonly used to identity chemical components [1].
A short description of laser-based spectroscopic methods and sensitive mass spectrometry is given, with emphasis on why these approaches are so selective and sensitive for the detection of trace gases.
The binuclear Cu2 + and Co2 + complexes of the receptors have been also prepared and characterized using spectroscopic methods and MALDI-TOF mass analysis.
The journal focuses on papers that show the scope and power of separation sciences when combined with spectroscopic methods, in particular with mass spectrometry.
