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The GC-MS spectra were recorded on Varian Saturn (mass spec model).
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Therefore, it is not understood, a priori, to what extent does a model constrained to pairwise correlations in the mass spec data captures known interactions.
Precise points of modification can be determined by mass spec analysis after cleavage.
"We want to do the same thing with the mass spec".
How, though, to make a mass spec small enough and robust enough to operate underwater?
Besides the vacuum, miniaturizing a mass spec poses other difficulties, too.
For Verbeck, the primary challenge in making a smaller mass spec was electrical.
Mass spec results are given as m/z in g/mol.
As more companies rely on mass specs to provide crucial data for quality control as well as proteomics and metabolomics investigations, "you're going to see more mass spec needs in industry," he asserts.
As with advanced mass spec imaging systems, this approach allows researchers to measure protein content cell by cell in situ.
"This is the next frontier of understanding proteomics data sets, and the mass spec is the key to that".
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