To be honest, we prefer experimental data that addresses binding such as those provided by our superspy mutants, and our crosslinking, mass spec and deuterium and protease protection experiments.
She works with scientists to design the experiments that run on the mass spec, analyzes the results, and interprets the data to determine whether proteins have been modified or degraded.
M.N. participated in the FISH experiments, and F.D. and D.L. performed the mass spec, and G.A. performed the statistical analysis.
As a next phase of the project, this library of theoretical peptides, which have already been scored for their likelihood of mass spec detection, will be compared to the experimentally deposited proteotypic peptides from a variety of LC/MS/MS experiments.
By combining the two experimental data sets Experiment = "MYRIAD_05" AND "PNNL_MS_09", we find 83 virus and human proteins with both mass spec and interaction data from each laboratory.
Precise points of modification can be determined by mass spec analysis after cleavage.
"We want to do the same thing with the mass spec".
How, though, to make a mass spec small enough and robust enough to operate underwater?
Besides the vacuum, miniaturizing a mass spec poses other difficulties, too.
