Sentence examples for mass reduction models from inspiring English sources

As previously observed for other WAT mass reduction models, the circulating level of leptin, secreted by white adipocytes, was significantly reduced in mice treated with D-WAT.

Wnt/ β-catenin activity was assessed during the development of fibrotic remodeling in the rat 5/6 renal mass reduction model.

This study aimed to elucidate if the rat 5/6 renal mass reduction model (RMR) is a good model for the Wnt/ β -catenin activation and possible next modulation.

This study aimed to elucidate if the 5/6 renal mass reduction model is a good model for the Wnt/ β-catenin activation and possible next modulation.

The 4/6 renal mass reduction model is used as a milder variant since it does not induce hypertension, and only moderate renal dysfunction and glomerulosclerosis [ 29, 30].

In a prevention-type study, remarkable reductions in proteinuria and glomerulosclerosis were observed after selective blockade of ETA receptors in a rat renal mass reduction model of hypertensive glomerular disease [ 86].

To do this, we used 5/6 renal mass reduction model animals and we sacrificed animals at 12 and 18 weeks after the surgery, when CKD is well established, and then we characterized the fibrosis establishment and the Wnt activation.

In their paper, authors confirmed that activation of Wnt/ β-catenin pathway was involved in 5/6 renal mass reduction model (RMR) and suggested that RMR is nice animal model for aberrant activation of Wnt/ β-catenin pathway to perform experimental therapy by various molecules.

Different models of renal mass reduction have been used to study the mechanisms of the progression of CKD in humans.

The modelling results suggest that short term benefits are obtained and related to mass reduction at the sites where the model was tested.

In summary, sitagliptin treatment attenuated renal dysfunction and structural damage in a model of renal mass reduction.