Mass production of differentiated cells with the functional morphology and characteristic marker expression of RPE cells is now possible (Maruotti et al., 2013).
Glioblastoma (GBM) stem cells (GSCs), responsible for tumor growth, recurrence, and resistance to therapies, are considered the real therapeutic target, if they had no molecular mechanisms of resistance, in comparison with the mass of more differentiated cells which are insensitive to therapies just because of being differentiated and nonproliferating.
In a seeming reprise of "The Raft of the Medusa" titled "Building the Boat While Sailing," this vocabulary is pushed to the limit by a crowd of characters who work, perform, emote and loll about, a mass of carefully differentiated humanity and accouterments.
Classically, the most well described type of regeneration is the epimorphic regeneration, characterized by the formation of a blastema, a mass of less differentiated cells that gives rise to the new structure functionally equivalent to the lost one (Morgan, 1901; Kragl et al., 2009).
Mass customization capabilities enable firms to design, produce, and deliver a high volume of differentiated products that meet specific customer needs in a timely manner and at close to mass-production prices.
Underlying mesenchymal cells communicate with the apical epithelial cap, and form the blastema, which is considered as a mass of de-differentiated cells (Akimenko et al., 2003; Poss et al., 2003).
Glioblastoma (GBM) stem cells (GSCs), responsible for tumor growth, recurrence, and resistance to therapies, are considered the real therapeutic target in comparison with the mass of insensitive and differentiated tumor cells [ 1].
This clonogenic tumoral subpopulation is the only one able to originate a tumor mass containing the variety of differentiated cells present within the original tumor and, for this reason, these cells were described as cancer stem cells.
She was found to have a cecal mass of moderate to poorly differentiated adenocarcinoma.
In turn, MTOR stimulates specific functions of differentiated cells and cellular mass growth.
