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Doses were normalized across rodent species, strain, and sex as the estimated deposited particle mass dose per gram of lung.
Caffeine was administered in two doses – a 2.5 mg · kg−1 body mass dose 1 hour before the exercise protocol, and a 5 mg · kg−1 body mass at 90 minutes into exercise.
There were no differences in groups with respect to age or raclopride mass dose that could account for the difference in D2/D3 receptor availability.
The lower effect per unit mass dose seen with Sterling V is consistent with earlier studies showing that particle surface area of low toxicity particles is a more appropriate dosemetric for induction of inflammation in the lungs than particle mass (Oberdörster et al., 1994, 2001; Brown et al. 2001; Donaldson et al., 2002).
Although the retained mass dose of Sterling V at the end of exposure was even higher than for Printex 90 (50 mg/m3 exposure group) (∼7.6 vs 4.8 mg), the surface area of the retained Sterling V was similar to that of the retained Printex 90 of the mid-dose exposure (7 mg/m3) (∼0.2 m2 in both groups).
JNJ42259152 is a PDE10A inhibitor, so potentially a mass dose effect need to be taken into consideration.
Similar(17)
Some scientists and campaigners have lobbied public health authorities for mass dosing of vitamin D in Scotland.
The water and feed are medicated with drugs to control parasites or with mass doses of antibiotics as necessary.
But he is not an advocate of mass doses of antibiotics: he forecast emergent resistant organisms as the next infectious disease problem even before the Cipro craze.
Chloroquine was widely effective around the world, but began to lose its grip on malaria after mass dosing in endemic areas.
Mass doses were 0.1 g/kg gelofusine and 1 g/kg L-lysine.
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