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Here we show that 2ME2 also has direct effects on bone to increase bone mass by decreasing osteoclasts and increasing osteoblasts.

We demonstrated for the first time that oxidative stress induced a significant loss of mitochondrial mass by decreasing mitochondrial number and volume density in the ONH astrocytes.

Experimental studies in APOE*3-Leiden.CETP mice have demonstrated that statins decrease plasma CETP mass by decreasing hepatic mRNA expression, again related to decreased hepatic cholesterol content (4).

Thus, we hypothesized that the increase in circulating bile acid concentrations after IT surgery might have contributed to the improvements of insulin sensitivity and β-cell mass by decreasing ER stress.

Thus, increased circulating concentrations of GCs cause an increase in body fat mass specifically by enhancing fat deposition in the visceral compartment and reducing peripheral stores (31); GCs also reduce skeletal muscle mass by decreasing the rate of protein synthesis and by increasing the rate of protein breakdown and increase whole-body lipolysis, resulting in dyslipidemia (32).

This suggests that cytokines such as tumour necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), interferon-γ (IFN-γ) and leukaemia-inhibitory factor (LIF), which have been proposed to decrease adipose tissue mass by decreasing synthesis of triglycerides through inhibition of LPL (Berg et al, 1994) probably play a minor role in the loss of lipid from human adipose tissue.

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The effect of the stiffness of the distributed attached mass is decreased by decreasing the radii of curvatures or increasing the thickness of the shells.

14 Physical activity may be important to decrease the effects of some comorbidities such as lipodystrophy by increasing muscle mass, decreasing obesity by decreasing overall adipose tissue, and improving immune function by increasing T cells.

Bmal1−/− mice exhibit reduced muscle mass accompanied by decreased diameter and number of muscle fibres [ 21, 22].

Sirt1+/− heterozygous female mice exhibit a reduction in bone mass characterized by decreased bone formation and increased marrow adipogenesis (Cohen-Kfir et al, 2011).

The decrease in particle size is indicative of a change in the physical structure of the biomass and could result in an increase in digestibility by decreasing mass transfer resistance or by increasing the exposed external surface area of the biomass particles.

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