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(The original marrow would have been destroyed by the high toxicity of the purported cure).
If TLR3 negatively controlled the number of CD4+ T regulatory cells, the WT mice reconstituted with Tlr3 −/− bone marrow would have less CD4+ T regulatory T cells.
Moreover, supplementary iron was not provided to patients whose relatively dormant bone marrow would have been stimulated by the ESA, thereby depleting iron stores available for metabolic functions other than Hb production [ 2, 3, 9, 10].
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A likely candidate is fatty yellow bone marrow which would have decreased the density of these bones compared to a fill of red bone marrow in the juveniles.
The bone marrow transplant would have to wait until he was stronger.
On the other hand, cells derived from older donors were obtained by collecting bone marrow, which would have been discarded, at hip surgery.
As the authors mention, it may be that the chosen specific endpoint of MRI cartilage loss was the problem here: perhaps bone marrow lesions would have had a stronger association.
For instance, drugs that allow leukemia patients to get well enough to progress to a potentially curative but very costly bone-marrow transplant would have a poor price profile because, in the end, they increase total spending.
These mice had meanwhile been irradiated to destroy bone marrow cells and would have died without the new cells.
In this patient, bone marrow radiation dose would have limited the maximum amount of administrable 90Y-DOTATOC.
However, for bone marrow, five patients would have received more than 1.8 Gy, which is close to the MTD, estimated around 2 Gy [30].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com