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Busulfan is contraindicated in the presence of leukocytes <4 × 10/l or platelets <100 × 10/l, as the drug accumulates in the bone marrow, where it continues exerting its effect for several weeks.
This substance is then transported through the plasma to the bone marrow, where it accelerates the production of red cells.
Transferrin, also called Siderophilin, protein (beta1 globulin) in blood plasma that transports iron from the tissues and bloodstream to the bone marrow, where it is reused in the formation of hemoglobin.
The iron removed from hemoglobin passes back into the plasma and is transported to the bone marrow, where it may be used in the synthesis of hemoglobin in newly forming red cells.
A "bone-seeker," strontium-90 is chemically similar to calcium, so the body deposits it in bone and marrow, where it is known to cause cancer.
It travels through the blood to the bone marrow, where it binds to receptors on stem cells and triggers them to mature into red blood cells.
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One HSC gives rise to 2 daughter cells, one of which remains as a pluripotent stem cell and the other migrates to the main bone marrow compartment, where it differentiates to its progenies [ 2, 3].
In fact, oxygen level around or below 1% is a concentration normally experienced by the most immature hematopoietic progenitors in the bone marrow niche, where it appears a critical component of stemness maintenance [ 12, 13].
Influence of HLA-C has also been examined in bone marrow transplantation where it turns out to be a greater predictor of graft versus host disease compared to HLA-A and -B [ 18].
Osteopontin is secreted by osteoblasts in the bone marrow niche where it is thought to play an important role in the maintenance of HSC quiescence and maintenance of 'stemness' [ 20].
Methanol acts as a Trojan horse: It's carried into susceptible tissues in your body, like your brain and bone marrow, where the alcohol dehydrogenase (ADH) enzyme converts it into formaldehyde, which wreaks havoc with sensitive proteins and DNA.
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Justyna Jupowicz-Kozak
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