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hMSCs isolated from adult bone marrow were directed to osteoblast differentiation on the coated plates.
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In several other cases, antibodies have been described in PRCA patients' sera that were selectively cytotoxic for marrow erythroid cells or were directed against EPO [ 7– 9].
The relationship between the niche microenvironment and metastasis was first demonstrated by the characterization of bone marrow-derived cells that were directed to and colonized the pre-metastatic niche [ 65].
In particular, studies have highlighted that MSCs obtained from bone marrow could be used in cartilage repair procedures as bone marrow stromal cells (BMSC) can be directed towards the chondrogenic lineage [21].
Thousands of patients worldwide are currently alive more than 5 years following bone marrow transplantation and increasing attention is being directed to potential late complications (Sullivan et al., 1991).
Second, efforts should be directed toward inducing bone marrow recovery.
Future developments are directed to yield comprehensive information about bone marrow structure, function and microenvironment.
Current investigation is directed towards high-dose therapy with autologous bone marrow transplant.
Continuing studies are directed toward exploring the potential regulatory interactions between satellite cells and bone marrow-derived cells that regulate fibrosis and other age-related changes of muscle.
One possible mechanism for false-positive staining of HCs in bone marrow is a direct reaction between specific HCs and alkaline phosphatase (AP) [ 18] using the chromogenic visualisation technique.
Therefore, the apoptotic resistance of pro-B cells in aged bone marrow is likely the direct consequence of reduced SLC expression.
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