The bone marrow is defined as a hypoxic space with low oxygen tension.
Hypercellular marrow is defined as more than 70%, normocellular marrow as 30 70%, and hypocellular marrow as under 30% bone marrow [ 9].
Andreas Trumpp Hematopoietic stem cell (HSC) niches in the bone marrow are defined as the cellular and molecular microenvironment that regulates HSC function [ 77].
Bone marrow changes suggestive of bone marrow oedema were defined as lesions within the trabecular bone, with ill-defined margins and high signal intensity on T2-weighted fat-saturated images, and low signal intensity on T1-weighted images.
Subarticular bone marrow abnormalities were defined as poorly marginated areas of increased signal intensity in the normal subchondral and epiphyseal bone marrow on T2-weighted FSE fast-suppressed MR images.
Bone marrow lesions were defined as areas of increased signal intensity adjacent to subcortical bone in either the distal femur or the proximal tibia [ 16, 17].
Summation of the score was regarded as an indication of severity of bone lesions, while prevalent bone marrow lesions were defined as a total score of 1 or more.
MSC-precursor is a rare population of cells residing in the bone marrow that were defined by the presence of CD271 expression and, respectively, low or absence of pan leukocyte antigen CD45 expression.
For organs with activity concentrations clearly exceeding background levels [liver, gall bladder, upper large intestine (ULI), urinary bladder, heart wall, bone marrow in vertebrae], ROIs were defined on the PET scan with the highest tracer uptake (Fig. 1) using a 50% isocontour.
Inflammatory MOs in bone marrow, blood, and spleen were defined as CD11b+ cells with high expression of Ly6C.
