In our study, however, we only documented intramedullary hemophagocytosis and considered that any phenomenon occurring in the bone marrow was associated with a central mechanism.
However, we have previously shown that hemozoin may directly inhibit erythroid development in vitro and the levels of hemozoin in plasma from patients with malarial anemia and hemozoin within the bone marrow was associated with reduced reticulocyte response.
For example, in patients with breast cancer, several studies suggested that the presence of disseminated tumor cells in bone marrow is associated with a poorer prognosis [ 12, 13].
In the latter study, the detection of more than three tumour cells in bone marrow was associated with poorer survival particularly in N0 and T1/T2 subsets.
In conclusion, we demonstrated that low miR-144 expression in cancer cells metastasised to the marrow is associated with GC progression.
Using the 5TMM mouse model of myeloma disease, Asosingh et al., showed that myeloma plasma cell infiltration into the bone marrow was associated with a decrease in hypoxia, relative to the control.
Detection of BMM in rib marrow is associated with increased risk of cancer-related death at 10 years in all patients and is independently prognostically significant in patients who do not receive CRT prior to surgery.
In this study, we show that most mesenchymal activity and chondrogenic capacity in the fetal bone marrow is associated with nestin− MSCs, but that these rapidly differentiate towards committed osteochondral lineages early in postnatal life.
Cryopreservation of harvested bone marrow is associated with erythrocyte disruption and requires the addition of dimethyl sulfoxide (DMSO), of which high concentrations may cause in vivo haemolysis during infusion [ 44]; however, haemoglobinuria due to marrow infusion rarely leads to ARF [ 44].
For patients with breast cancer, several studies demonstrated that the presence of ICC-stained cytokeratin-positive cells in the bone marrow is associated with a poor prognosis (Diel et al, 1996; Braun et al, 2000; Janni et al, 2000; Gerber et al, 2001; Singletary et al, 2002; Wiedswang et al, 2003).
