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No severe bone marrow toxicity was observed in this study even when therapeutically effective amounts were administered.
Bone marrow toxicity was monitored by counting red blood cells, white blood cells, and platelets in arterial blood samples with a Vet CA530 Medonic Cell Analyzer (Boule Medical, Stockholm, Sweden) twice a week for the first 4 weeks, then once weekly until the end of the study.
Marrow toxicity was similar to that observed during conventional treatments.
No specific bone marrow toxicity was observed with fidaxomicin in the nonclinical studies [ 13].
Recovery from bone marrow toxicity was confirmed before initiation of a further course.
Following the single therapy cycle, bone marrow toxicity was mild in most patients (grades 1 2 in 30% of patients).
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Cumulative bone marrow toxicity is also increased in patients receiving additional chemotherapy.
The importance of chromosomal aberrations as a proximate cause of bone marrow toxicity is discussed.
Systemic AEs, such as mucositis, alopecia, and bone marrow toxicity, were not observed in either treatment group.
Especially in the current era of targeted agents where bone marrow toxicity is less common, the amount of prior treatment is less of a concern.
However, the complete pattern of benzene metabolites formed in the liver and their role in bone marrow toxicity are not fully understood.
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