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Exact(7)
In contrast, pathologic stimulation of a single lineage of cells, via Epo for example, results in a homogeneously (erythroid) hyper cellular bone marrow that is sufficient to maintain elevated hematocrit.
In humans, nucleated cells are isolated from the aspirate of bone marrow that is typically harvested from the superior iliac crest of the pelvis via trocar [ 9].
A matched unrelated donor marrow that is 10/10 (considering HLA-A, -B, -C, -DRB1, -DQ) using high-resolution typing provides excellent outcomes.
These changes could provide an attractive explanation for the increased adiposity of bone marrow that is seen with age, and may be a factor in senile osteoporosis [ 41, 42].
Therefore, disease outside the bone marrow or even disease within the bone marrow, that is, not in the area sampled, may be missed for MRD assessment.
The spread in bone also follows the distribution of adult red bone marrow, that is, skull, thorax, pelvis, spine, proximal long bones (Imbriaco et al, 1998; Scher, 2003), subsequently progressing to involve adjacent cortical bone.
Similar(53)
Both problems, Dr. Gosden observed, would suggest that the female's germ-line stem cells, if they do indeed exist, are exceptionally fragile and sensitive to aging, faltering and dying off well in advance of other adult stem cells, like those in the testes, or those in the bone marrow that are the progenitors to new blood and immune cells.
The results obtained show that mice treated with AZT+DDI+GSH-loaded erythrocytes showed proviral DNA content in the brain and in macrophages of bone marrow that was significantly lower than in mice treated with AZT+DDI.
Four healthy volunteers were donors of normal bone marrow that was pooled for assay normalization.
Neuroblastoma relapse is caused by a minimal residual disease, characterized by the presence of a small number of cancer cells in the blood and/or in the bone marrow that are resistant to conventional therapies.
RT-PCR could detect micrometastatic prostate cancer cells in the bone marrow that were not detectable by bone scan imaging.
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