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Exact(8)
Both problems, Dr. Gosden observed, would suggest that the female's germ-line stem cells, if they do indeed exist, are exceptionally fragile and sensitive to aging, faltering and dying off well in advance of other adult stem cells, like those in the testes, or those in the bone marrow that are the progenitors to new blood and immune cells.
Neuroblastoma relapse is caused by a minimal residual disease, characterized by the presence of a small number of cancer cells in the blood and/or in the bone marrow that are resistant to conventional therapies.
It is tempting to speculate that particularly tumour cells lodging in the bone marrow, that are responsible for bone metastases, may spill over into the blood and circulate through the body.
NPC1-YFP immunofluorescence was also absent from the spleen and restricted to a few cells in the thymus and bone marrow that are not Thy1.2 positive (Fig. 5C and D).
In the second half of the 19th century, it was determined that the skeleton is filled with areas containing yellow or red marrow that are distributed in a defined pattern.
However, effective GVT reactivity is mediated by cytotoxic cells derived from the bone marrow that are anergic to host MHC, indicating that tumour associated antigens are the primary targets of this reaction.
Similar(52)
The results obtained show that mice treated with AZT+DDI+GSH-loaded erythrocytes showed proviral DNA content in the brain and in macrophages of bone marrow that was significantly lower than in mice treated with AZT+DDI.
Four healthy volunteers were donors of normal bone marrow that was pooled for assay normalization.
In contrast, pathologic stimulation of a single lineage of cells, via Epo for example, results in a homogeneously (erythroid) hyper cellular bone marrow that is sufficient to maintain elevated hematocrit.
RT-PCR could detect micrometastatic prostate cancer cells in the bone marrow that were not detectable by bone scan imaging.
In humans, nucleated cells are isolated from the aspirate of bone marrow that is typically harvested from the superior iliac crest of the pelvis via trocar [ 9].
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