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Pancytopenia because of bone marrow suppression is the most severe complication of ARO [1].
Bone marrow suppression is the most recognized form of IR-induced damage after WBI in mammals, leading to irreversible depletion of the bone marrow stem cell reserve.
Bone marrow suppression is the single most potent, clinically preventable, proangiogenic stimulus related to conventional treatments.
However, bone marrow suppression is considerable, limiting its use in combination with other chemotherapeutic agents.
Bone marrow suppression is thought to be the main mechanism in which interferon causes thrombocytopenia and neutropenia [ 39].
Docetaxel-induced toxicity, especially bone marrow suppression, is reported to be influenced by such polymorphisms [ 8– 11].
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Bone marrow suppression was not identified during Phase III trials, in which treatment did not exceed 21 days.
Drug-induced bone marrow suppression was suspected.
Zidovudine-induced bone marrow suppression was considered.
Patients who developed grade 4 bone marrow suppression were assessed every 1 2 days.
Adverse events, especially bone marrow suppression, are another concern regarding the use of linezolid to treat VRE bacteremia.
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