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In addition, bone marrow explorations resulted in identification of alternative mechanisms of bone marrow suppression in 73 (24.5 %) patients.
2. Stover J, Stocker R. Barbiturate coma may promote reversible bone marrow suppression in patients with severe isolated traumatic brain injury.
In space, there is bone marrow suppression in which blood cells that fight infections and even cancer cells are reduced which puts people at risk for developing infectious diseases and cancer.
High levels of IFNγ, which was previously called macrophage activating factor, may contribute to bone marrow suppression in HLH.
Alternatively, it might reflect azathioprine-induced bone marrow suppression in the AP protocol group [ 8].
There were no cases of liver abscess, alopecia, skin changes, and bone marrow suppression in this series.
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The same mechanism may be involved in the inhibition of TS-1-induced leukopenia/bone marrow suppression demonstrated in the present study; however, further extensive studies are necessary to clarify this point.
ii) Bone marrow suppression: changes in hemoglobin, platelets, and white blood cells (WBCs).
It is also important to bear in mind that many of these patients have metastatic bone disease and bone marrow infiltration−thus, the bone marrow suppression may in some instances result from the disease rather than the treatment itself.
Bone marrow suppression resulting in thrombocytopenia, anemia, and/or neutropenia can develop when IgG or IgM antibodies bind to antimicrobial antigens on the surface of circulating cells, leading to lysis or opsonization of these cells [ 4]. β-Lactams, including imipenem, linezolid, and glycopeptides, have all been associated with various forms of bone marrow suppression [ 30, 41, 45, 46].
(Figure 1) Bone marrow suppression mainly occurred in group C, in which the treatment contains AZT and 3TC.
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