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URI protein expression was also observed in MM cells in bone marrow specimens of patients with MM.
The mRNA expression of 12 genes closely involved in the actions of cytosine arabinoside and anthracycline was evaluated by real-time reverse transcriptase PCR (RT PCR), in 54 diagnostic bone marrow specimens of M2-subtype AML.
To further assess the possible therapeutic value of the combination of AMCDs with Wee1 inhibition, the combination of MK-1775 and vincristine was tested on primary leukemic blasts from bone marrow specimens of four adult lymphoblastic leukemia patients.
In bone marrow specimens of 50 patients with early breast tumors, CD44+/CD24low/- phenotype in cytokeratin-positive cells was detected in 72% of all disseminated tumor cells (DTC) compared with less than 10% in primary tumors [ 52].
The study included examination of histological tumour and bone marrow specimens of the following diseases: nephroblastoma (n=24), leukaemia (n=24), retinoblastoma (n=18), neuroblastoma (n=17), rhabdomyosarcoma (n=14), medulloblastoma (n=11), Ewing's sarcoma (n=2), hepatoblastoma, neurofibroma and glioblastoma (n=1 for each).
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In the absence of difficult-to-obtain bone marrow specimens, microbiologic culture of a blood sample is considered to be the current state-of-the art test for the diagnosis of typhoid fever even though its sensitivity may be as low as 40% [ 4, 5].
Detection of F. tularensis in hare specimens, including bone marrow specimens, and lack of F. tularensis detection in samples of the water system used to rinse hares suggest infection of the hares.
In bone marrow specimens from two of five patients, there were clusters of Fc, and high-rate Feb mitosis was noted in one of them.
Adult marrow specimens are often of limited availability and rarely come from normal donors.
None of the bone marrow specimens stained positive for either of the remaining reagents: mAb MA454 or mAb 57B.
Non-metastatic bone marrow specimens from three out of four other patients were strongly positive for Fc, mostly Feb.
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