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5 days after insertion of the piston, when loading was normally to be started, the marrow pressure was measured before and after a 1.2-mm diameter hole was drilled through the bone under the piston, into the marrow cavity.
By definition, osteonecrosis means in situ death of bone cells, osteocytes, and hematopoietic and fatty marrow precursor cells, and it is most often thought to be due to bone marrow pressure (Kantor et al.1987) or an occult subchondral fracture (Yamamoto and Bullough 2000).
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Recent studies have revealed that induced marrow fluid pressure and bone strain by mechanical stimulation were dependent on dynamic loading parameters and optimized at certain loading frequencies [ 33].
In a rat tail suspension experiment, suturing tibial vein increased tibial marrow cavity pressure (ImP) (27.8 mmHg versus 16.4 mmHg, P < 0.05) in the experimental group compared to the control, which suggested that the pore fluid flow pressure reinforced by the suture is inversely proportional to the bone cross section.
Published toxicity (MAX2), diastolic blood pressure, marrow invasion and lactate dehydrogenase (LDH) were all associated with toxicity (P<0.1); Body Mass Index, previous chemotherapy, red blood cells, platelets, polymedication with dose-intensity; and polymedication with FACT-G change.
It has been revealed by a previous study [ 30] that increased marrow fat increases intraosseous pressure.
The implant was then inserted into the hole and pushed into the marrow cavity using finger pressure.
This study was designed to determine whether bone marrow fat cell size, intraosseous pressure, and blood flow rate differed between steroid-treated rabbits with ON and those without.
Univariate Cox regression analysis identified that systolic blood pressure, low bone marrow cellularity, megakaryocyte distribution, and M/E ratio were significantly associated with mortality (Table 6).
Even when we drilled a hole through the bone surface under the piston, the pressure in the marrow cavity was only moderately increased.
On the basis of observations made in the murine thymic lymphoma model, we would expect an increase in bone marrow cellularity, thus relaxing proliferative pressure and delaying further transformation from MDS to MDR-AML.
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