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This study used the new R-mCT system to examine the dynamics of marrow penetration within a titanium cap in rabbit calvarium.
These include: 1) very similar progenitor differentiation capabilities; 2) important cellular subsets (such as mesenchymal and perivascular cells) are found in much higher concentrations compared to bone marrow aspirants (>1500X); 3) less expensive to harvest; 4) less invasive (safer); 5) readily available tissue; and 6) less technically demanding than bone marrow penetration and cellular harvest.
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Increasing the intrinsic repair has traditionally been focused on the recruitment of chondrogenic cells (MSCs) from the bone marrow by penetration of the subchondral bone by drilling or microfracturing (MFx) [ 20].
Solid knowledge of how the trabecular area is distributed within the proximal tibia and experience of the surgeon helps to avoid injections into the bone marrow and/or penetration of the caudo-lateral cortex of the tibia with the needle.
Radium-223, a novel α-emitting radiopharmaceutical, targets bone metastases with high-energy, short-range irradiation, thus preserving bone marrow and limiting penetration to adjacent tissues [ 20].
Such infiltrate was dense and highly vascularized in superficial regions of the marrow adjacent to synovial penetration through cortical bone (bone erosions), whilst was milder (< 50% infiltrates/tissue area) in more central areas.
We know that all sockets inserted in both ceramic and cadaveric bone were implanted under good conditions, due to a dry acetabulum without any blood or bone-marrow to disrupt cement penetration (Krause et al. 1982, Ranawat et al. 1995).
The aim of this study was to compare three resorbable biomaterials regarding seeding efficacy with human bone marrow stromal cells (BMSCs), cell penetration into the matrix, cell proliferation and osteogenic differentiation.
The penetration of the bone marrow stromal stem cells into the scaffolds and the attachment of the cells onto the scaffolds were also investigated.
This characteristic mechanism spares bone marrow as a result of lower penetration to surrounding tissues and limits toxic effects compared with traditional β-emitting radiopharmaceuticals [ 20].
In addition, Sr emits higher-energy beta particles, resulting in greater tissue penetration and consequently higher bone marrow toxicity.
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