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PTX3−/−-MSCs were isolated from the bone marrow of PTX3-knockout mice.
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To determine if there is any potential regulatory role of Nur77 in osteoclastogenesis, we compared osteoclast differentiation cultures from bone marrow hematopoietic progenitors of Nur77 knockout (Nur77 KO) mice and WT littermate controls.
This is in line with previous findings that bone marrow-derived macrophages of USP18 knockout mice have increased chemokine and chemokine receptor expression after exposure to IFN β.
Thus, Rps27l is required for postnatal development of some organs, particularly thymus, spleen and bone marrow, and postnatal death of Rps27l knockout mice is likely associated with enhanced apoptosis, leading to bone marrow depletion.
Molecular validation of APIP12 knockout mutant.
(B and C) Analysis of the effect of Nedp1 knockout (B) or Ubc12 knockout (C) on PCNA-polη interaction in response to H2O2 treatment.
Their knockout/wild-type ratios indicate relative changes of protein acetylation levels in the livers of HDAC6 knockout mice vs. wild-type mice.
The generation of Asic3 knockout (Asic3−/−) mice was as described[21].
The generation of ZAS3 knockout mice has been described [15].
(A ) Characterization of the stem/progenitor cell compartment of Lsd1 knockout mice demonstrated the presence LT-HSCs (CD150+ CD48− LSK), while having lost all LS−K+ myeloid progenitor cells (i.e., CMP, GMP, and MEP) in the bone marrow.
In bone marrow from mdr1a1b /– knockout mice, a normal percentage of SP cells was obtained, suggesting that MDR1 is not correlated with the SP cells identified by Hoechst (Uchida et al, 2002).
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