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The diagnosis of ALL was based on bone marrow morphology and immunophenotyping.

However, these agents have to date not been shown to significantly improve cytopenias, restore normal bone marrow morphology, and induce cytogenetic remissions in MF patients.

The two others were also positive for active disease prior to transplantation by marrow morphology, and likely represent successful cures by allo-SCT.

APL is usually diagnosed on the bone marrow morphology and confirmed by the presence of the t(15 17) and detection of the PML/RARA fusion transcript via RT-PCR [ 3].

Secondary objectives encompassed TI on the combination of Aza+ESA, effect on bone marrow morphology and biology, peripheral blood parameters, cytogenetics, safety and response in relation to mutational status.

Similar(55)

Diagnoses were carried out on the basis of clinical features, blood counts, peripheral blood films and bone marrow morphology including cytochemical staining and immunocytochemistry where available.

Patients were stratified into intermediate risk (IR) and high risk (HR) groups according to cytogenetic aberration, prednisone response, bone marrow morphology at day 15 and 33, and MRD levels (The details of stratification criteria and treatment protocols were described in Additional file 1: Table S1, S2, S3).

Predictive values of early treatment responses, including prednisone response, bone marrow morphology at day 15 and day 33 during induction chemotherapy, and minimal residual disease (MRD) monitored by flow cytometry after induction therapy (time point 1, TP1) and before consolidation therapy (time point 2, TP2), were analyzed.

The predictive values of early treatment responses, including prednisone response, bone marrow morphology at day 15 and day 33 during induction therapy, MRD levels after induction and before consolidation therapy, and their correlations were analyzed.

The final study population (Table  1) with suspected hematologic malignancy/disease and bone marrow morphology assessment included 1,387 GX, 4,162 LL, and 19,115 OL patients.

However, multivariate analysis showed that treatment response (bone marrow morphology on day 15 and 28) was the only independent prognostic marker (RR = 4.39; 95 % CI, 1.97 9.78).

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