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Dr. Shahin Rafii, a blood specialist at the Weill Medical College of Cornell University in New York, believed that stem cells from the bone marrow might be involved in creating the new blood vessels induced by tumors.
Bone marrow might be a reasonable first step, but before we slide down into the non-renewable organ portion of the slippery slope, let us see how many lives we can save through a policy of presumed consent where organ donation is the default on all drivers' licenses and a driver must opt-out to withhold organs upon death.
Labeling of the bone marrow might be a specific reaction, since CXCR4 is known to be expressed in hematopoietic stem cells.
Bone marrow might be an additional source of vascular progenitor cells that can contribute to the repair and remodeling of vessel walls.
Fractures in cancellous metaphyseal bone tend to heal by direct bone formation within the injured marrow compartment, suggesting that mesenchymal cells residing locally in the marrow might be sufficient for the bone regenerative process.
Therefore, the potential of agents such as EPO (Yip et al., 2011) or granulocyte-macrophage colony-stimulating factor (Subramaniyam et al., 2009) to promote mobilization of cells from the bone marrow might be a more attractive option.
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Meat from megafauna carcasses offered the highest calorific yield available for any savannah-dwelling species (bone-marrow might be richer ounce for ounce, but quantities were far smaller).
In doubtful cases of haematological compromise, a bone marrow biopsy might be indicated to assess bone marrow status in pretreated patients and to assess the risk when planning for multiple PRRNT cycles (e.g. intervals between cycles).
This is in analogy with the lack of bone marrow toxicity, discussed above, i.e., the low bone marrow toxicity might be due to the lack of binding of 227Th-trastuzumab or 223Ra to bone marrow cells.
The increased expression of proinflammatory cytokines in bone marrow adipocytes might be associated with a high level of macrophage infiltration within the aged bone marrow environment; however, as mentioned, we did not detect significant differences in macrophage contamination of the adipocyte preparations isolated from bone marrow versus epididymal depots.
Until recently, researchers thought mammals couldn't produce any new neurons after childhood--much less that foreign bone marrow cells might be coaxed into achieving such a feat.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com