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The interaction between MM cells and the bone marrow microenvironment stimulates the proliferation and migration of endothelial cells.
The interaction between MM cells and the bone marrow microenvironment stimulates the proliferation and migration of endothelial progenitor cells (EPCs).
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Multiple myeloma pathophysiology in the non-Gaucher population involves genetic abnormalities within the tumour and interaction between myeloma cells and the bone marrow microenvironment where the activation of signalling pathways stimulates the expansion of the malignant clone (Bommert et al, 2006).
In CKD patients, vitamin D deficiency may stimulate immune cells within the bone marrow microenvironment to produce cytokines, inducing impaired erythropoiesis.
Interestingly, bone marrow microenvironment is also a critical reservoir for DTCs.
BCP-ALL cells critically depend on interactions with the bone marrow microenvironment.
The decline in total bone marrow hematopoietic cells is accompanied with elevated adipocytes into the marrow cavity, thereby inhibiting hematopoiesis and recovery of the bone marrow microenvironment.
These malignancies affect normal homeostasis and reshape the bone marrow microenvironment.
Upon infection, however, neutrophils are recruited from the bone marrow microenvironment and lose these pro-survival signals.
The bone marrow microenvironment is vital to the development, differentiation, and regulation of the lymphohematopoietic system.
This tissue-engineered bone marrow microenvironment could be readily manipulated in situ to understand the biology of bone metastasis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com