Sentence examples for marrow microenvironment provides from inspiring English sources
Background: Leukemic cell adhesion to proteins of the bone marrow microenvironment provides signals which control morphology, motility and cell survival.
The bone marrow microenvironment provides protection to acute lymphoblastic leukemia (ALL) cells against drug treatment and is a frequent site of leukemia relapse.
While the mechanisms have not been fully elucidated, it is clear that obesity-related chronic inflammatory stimuli to the bone marrow microenvironment provide a unique niche for interaction between mesenchymal stromal/stem cells (BMSCs) and hematopoietic stem cells (HSCs) [ 40].
The identification of proliferation/survival pathways constitutively activated by genetic alterations in multiple myeloma (MM), or sustained by the bone marrow (BM) microenvironment, provides novel opportunities for the development of targeted therapies.
These data suggest a potential benefit of TMI that could diminish impairment of the marrow microenvironment and provide similar results as HDM200.
Tumor microenvironment provides the advantage of the passive drug targeting.
Potential targets, including NOTCH and WNT pathways, the chemokine receptor CXCR4 and adhesion molecules, are all likely to have a role in the leukaemic stem cell microenvironment provided by the bone marrow niche (reviewed in Lane et al, 2009).
These factors are secreted by bone marrow-derived stem cells in the bone microenvironment, providing a supportive niche that facilitates cancer cell survival and proliferation [ 61, 62].
Therapeutic targeting of these stromal cells within the bone marrow microenvironment, specifically MSCs and osteoblasts, may provide a novel mechanism of inhibiting MM disease progression.
Hematopoietic stem cells reside in specific niches in the bone marrow and give rise to either more stem cells or maturing hematopoietic progeny depending on the signals provided in the bone marrow microenvironment.
This review provides an overview of the bone marrow microenvironment and its involvement in normal, physiological HSC maintenance and plasma cell growth throughout MM disease progression.
