Sentence examples for marrow microenvironment in from inspiring English sources
A proto-oncogene BCL6 is up-regulated in the bone marrow microenvironment in multiple myeloma cells.
The study of myelodysplastic syndromes (MDS) in murine models has now indicated the possible involvement of the bone marrow microenvironment in the generation of dysplastic hematopoietic cells.
The bone marrow microenvironment, in which adult stem cells are maintained in healthy individuals, has been implicated as a source of chemoresistance and disease relapse.
Understanding of and further research into the role of the bone marrow microenvironment in leukemia progression and relapse are crucial towards developing more effective treatments and reduction in patient morbidity.
This review will highlight the importance of bone marrow microenvironment in maintaining bone marrow HS/PC populations and the contribution of these key populations in microvascular repair during the natural history of diabetes.
Because multiple and distinct ossicles can be generated in a single animal, this versatile system may be used to: (a) elucidate cellular/molecular mechanisms in bone regeneration; (b) study cell-to-cell interactions in the bone marrow microenvironment in health and disease; and (c) evaluate the efficacy of osteotropic agents that modulate bone turnover in vivo.
The role of the bone marrow microenvironment (BMM) in driving disease progression is widely recognized, with chemokine receptors (CXCR4), adhesion molecules, signal transduction pathways and hypoxia-related proteins playing a role [18,19,20,21,22,23,24,25,26].
The importance of ARTEMIS in primary MSC derived from the bone marrow microenvironment was tested in detail using knockout mice [ 26].
(9) The previous studies have demonstrated the bone marrow microenvironment is hypoxic in MM patients(10) and determined the role of hypoxia in progression and dissemination of MM mouse models.
Balderman SR, Li AJ, Hoffman CM, Frisch BJ, Goodman AN, LaMere MW, et al. Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome.
The hMSC-TERT expresses all known markers of primary hMSCs and exhibit 'stemmness' characteristics by being able to form bone and bone marrow microenvironment when implanted in vivo.
