Sentence examples for marrow microenvironment contributes from inspiring English sources

The pathways modulated by MSCs in the presence of MM cells may therefore represent important mechanisms through which the bone marrow microenvironment contributes to MM disease development.

Bone marrow microenvironment contributes to regulate self-renewal, commitment, differentiation, proliferation and the dynamics of apoptosis of hematopoietic progenitors [ 47], and CD34+ progenitor cells are known to be severely impacted in MDS by the composition of micro environmental stimuli [ 48].

Clonal evolution of MM cells and bone marrow microenvironment changes contribute to drug resistance.

It is likely that SCF expressed by stromal cells in spleen and marrow microenvironments also contributes to the expansion of these proerythroblasts.

We, therefore, predict that methods that enhance HSC engraftment in the new bone marrow microenvironment and procedures that contribute to the HSC expansion will improve the efficiency of HSC transplantation in the elderly.

While remarkable progress has been made in characterizing genetic aberrations that may control these hematological disorders, it has also become clear that abnormalities in the bone marrow microenvironment might hit precursor cells and contribute to disease.

Furthermore, haematopoietic cell types, including macrophages, osteoclasts and T-lymphocytes, also produce cytokines and other factors that contribute to the function of the bone marrow microenvironment.

They convincingly demonstrated that differentiated osteoblasts, like sympathetic presynaptic neurons, can transport and catabolize NE and thus may contribute to NE clearance within the richly vascularized bone marrow microenvironment.

In multiple myeloma (MM), this interaction is primarily seen in the bone marrow microenvironment where malignant plasma cells adhere to fibronectin (FN) or stromal cells contributing to induction of cytokines involved in angiogenesis and osteoclastogenesis, and tumor cells survival, invasion and drug resistance.

Lymphodepletion due to the altered bone marrow microenvironment was observed in the ApcMin/+ mouse model of intestinal tumorigenesis [ 15], which indicates the lymphodepletion may contribute to the drop of anti-tumor immune and tumorigenesis.

The bone marrow microenvironment (BMM) is an established "site of sanctuary" for ALL, as well as myeloid-lineage hematopoietic disease, with signals in this unique anatomic location contributing to drug resistance.