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The bone marrow microenvironment contains specific anatomical areas (termed niches) that are highly specialised for the development of certain blood cell types, for example HSCs.
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Background: Leukemic cell adhesion to proteins of the bone marrow microenvironment provides signals which control morphology, motility and cell survival.
We assumed that the presence of clusters of hematopoietic cells, containing megakaryocytes and related with new bone formation, was indicative of reconstitution of the anatomy of the bone marrow microenvironment.
Interestingly, bone marrow microenvironment is also a critical reservoir for DTCs.
BCP-ALL cells critically depend on interactions with the bone marrow microenvironment.
Upon infection, however, neutrophils are recruited from the bone marrow microenvironment and lose these pro-survival signals.
The decline in total bone marrow hematopoietic cells is accompanied with elevated adipocytes into the marrow cavity, thereby inhibiting hematopoiesis and recovery of the bone marrow microenvironment.
These malignancies affect normal homeostasis and reshape the bone marrow microenvironment.
The bone marrow microenvironment is vital to the development, differentiation, and regulation of the lymphohematopoietic system.
This tissue-engineered bone marrow microenvironment could be readily manipulated in situ to understand the biology of bone metastasis.
Emerging data show that cell-extrinsic factors in the bone marrow microenvironment protect and support AML cells.
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