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Stage 4S: Age <1 year old with localized primary tumor as defined in Stage 1 or 2, with dissemination limited to liver, skin, or bone marrow (less than 10 percent of nucleated bone marrow cells are tumors).
However, a small amount of histopathological interstitial edema in the bone marrow (less than 30% of the surface area) is not detected by MRI.
The activity of F-FDG that will deliver doses of 200 rad to the red marrow (less than 5% damage in 5 years) [ 9] and also 300 rad were calculated using the Medical Internal Radionuclide Dosimetry formalism.
However, even when the donor cells were derived from mice that had been transduced with GFP-mTRF2 expressing bone marrow, less than 1% of total thymocytes were positive for GFP (data not shown).
A human F-FDG dose delivering 200 rad to the red marrow (less than 5% damage) was calculated to be 4.76 Ci for a 70 kg woman, and the dose to the tumors was calculated to be 220, 1100 and 2200 rad for SUVs of 1, 5 and 10, respectively.
12 According to these criteria, the MGUS diagnosis requires a concentration of the serum M-component of less than 30 g/L, percentage of monoclonal plasma cells in the bone marrow less than 10%, and no sign of organ or tissue impairment related to myeloma, eg, hypercalcemia or lytic bone lesions.
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This has recently been confirmed by a study of bone marrow dosimetry during Lu-DOTATATE therapy indicating that the absorbed dose to the bone marrow is less than 0.2 Gy per treatment cycle of 7.4 GBq [ 24].
In 5/40 (12%) patients the bone marrow showed less than 20% blast cells.
Complete remission (CR) was defined as a normocellular marrow with less than 5% blast cells.
A CR required normalization of the marrow blasts (less than 5%%) and recovery of normal hematopoiesis with a neutrophil count of 1 × 10/l or more and a platelet count of 100 × 10/l or more in addition to disappearance of all clinical, laboratory, or radiologic evidence of disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com