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The uptake of radioactivity in red marrow is difficult to calculate because it is located within the bones, and 18 F-labelled radioligands might be metabolized through de-fluorination, leading to bone uptake of [18 F]fluoride ion.
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However, an increasing number of recent studies have shown that MSCs from bone marrow are difficult to obtain, have ethical issues and are easily contaminated.
Unfortunately, bone marrow architecture is difficult to preserve in transplantation studies, and future studies to address these possibilities will require conditional deletion of Lmna within select cell types of the bone marrow.
OS originates from stroma osteoblast in human bone marrow, and it is difficult to obtain the control corresponding to the OS tissue.
The differentiation of diffuse tumor involvement from the variable patterns of normal bone marrow is difficult and uncertain.
Because it is difficult to obtain marrow stromal cells (MSCs) from young HGPS patients, previous studies on the effects of progerin expression in MSCs were performed in human telomerase reverse transcriptase (hTeRT) immortalized cells [ 27].
Because of the high liver uptake it is difficult to evaluate the bone marrow in the lower thoracic and upper lumbar spine.
Although bone marrow culture would be the ideal gold standard, this test is difficult to perform in small rural hospitals in Africa.
Therefore, it is difficult to initiate the tigecycline therapy and bone marrow toxicity with a single-dose adjustment.
It is difficult to know how much lipofuscin was present in the initial donated bone marrow.
Vigilance is difficult to sustain.
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CEO of Professional Science Editing for Scientists @ prosciediting.com